I thought this might help with creating our rooms. Here are some environments from the game Amnesia. The environments really have an atmosphere about them and use lighting really well. In fact the lighting is really important in achieving the right atmosphere for the game. I'm not saying that we should make old style furniture (the game is set in the 1800's!) but we should aim to recreate the empty, lonely feeling you get from these rooms.
Aaaaand here's some concept art from Up, the indoors of the house (sorry bout the poor quality! I'll try n get better quality pics or bring the book in...).
Tangled (I think I will try and find more concept art, good example of a small room):